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Figure 1 | Gut Pathogens

Figure 1

From: Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?

Figure 1

Potential Pathways of the Gut-Brain-Skin Axis in Acne Vulgaris: [1] Psychological distress alone or in combination with [2] high fat diet, processed comfort foods devoid of fiber, cause alterations to [3] gut motility and microbiota profile [4]. Loss of normal microbial biofilm (Bifidobacterium in particular) causes intestinal permeability and endotoxins gain systemic access [5]. Burden of inflammation and oxidative stress is increased, substance P is elevated, insulin sensitivity is decreased due to endotoxemia [6]. In those genetically susceptible to acne vulgaris, this cascade increases the likelihood of excess sebum production, exacerbations in acne and additional psychological distress. Both probiotics and antimicrobials may play a role in cutting off this cycle at the gut level.

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