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Table 8 Amino acid polymorphisms in the sequence flanking the EPIYA motifs in 86 ABD subtypes

From: Diversity of 3′ variable region of cagA gene in Helicobacter pylori strains isolated from Chinese population

Disease

893

894

900

906

909

910

963

Total

N

S

 ~ 

E

T

 ~ 

A/N

Q

K

E

T

A

A

V

A

T

V/I

R

Q

L

CG

43 (86)

3 (6)

4 (8)

32 (64)

12 (24)

4 (8)

2 (4)

29 (58)

20 (40)

1 (2)

32 (64)

18 (36)

28 (56)

22 (44)

34 (68)

15 (30)

1 (2)

34 (68)

15 (30)

1 (2)

50

GC

12 (63.2)

0 (0)

7 (36.8) *

2 (10.5)

9 (47.4)

7 (36.8) c

1 (5.3)

14 (73.7)

5 (26.3)

0 (0)

10 (52.6)

9 (47.4)

10 (52.6)

9 (47.4)

12 (63.2)

7 (36.8)

0 (0)

12 (63.2)

7 (36.8)

0 (0)

19

GU

8 (100)

0 (0)

0 (0)

5 (62.5)

2 (25)

0 (0)

1 (12.5)

8 (100)

0 (0)

0 (0)

5 (62.5)

3 (37.5)

6 (75)

2 (25)

5 (62.5)

3 (37.5)

0 (0)

7 (87.5)

1 (12.5)

0 (0)

8

DU

4 (80)

1 (20)

0 (0)

4 (80)

0 (0)

0 (0)

1 (20)

5 (100)

0 (0)

0 (0)

2 (40)

3 (60)

3 (60)

2 (40)

4 (80)

1 (20)

0 (0)

3 (60)

2 (40)

0 (0)

5

MALT lymphoma

3 (75)

1 (25)

0 (0)

3 (75)

1 (25)

0 (0)

0 (0)

2 (50)

2 (50)

0 (0)

2 (50)

2 (50)

3 (75)

1 (25)

2 (50)

1 (25)

1 (25)

3 (75)

1 (25)

0 (0)

4

Total

70 (81.4)

5 (5.8)

11 (12.8)

46 (53.5)

24 (27.9)

11 (12.8)

5 (5.8)

58 (67.4)

27 (31.4)

1 (1.2)

51 (59.3)

35 (40.7)

50 (58.1)

36 (41.9)

57 (66.3)

27 (31.4)

2 (2.3)

59 (68.6)

26 (30.2)

1 (1.2)

86

  1. Amino acid polymorphisms in the sequence flanking the EPIYA motifs in 86 ABD subtypes strains isolated from Chinese population. N, asparagine; S, serine; E, glutamic acid; T, threonine; A, alanine; Q, glutamine; K, lysine; V, valine; I, isoleucine; R, arginine; L, Leucine. Wavy lines indicate gap. Numbers in parentheses are percentages. * The absence of amino acids 893 and 894 was significantly associated with GC (P < 0.01). The Glu deletion or substituted by other amino acids at residue 894, such as threonine (Thr) or asparagine (Asn), was significantly associated with GC (P < 0.05)