Table 5 Rate of mutations of genes associated with clarithromycin resistance development in the UM171, UM626A1, and UM650B
Locus tag | Protein ID | Protein name | Isolate | Rate of mutation | Threshold | Probability of mutation occurrence |
|---|---|---|---|---|---|---|
K747_RS06340 | WP_015644956.1 | Sel1 repeat family protein | UM171-B | 0.1054 | 0.0180 | 5.8387 |
UM171-R | 0.0948 | 0.0175 | 5.4160 | |||
UM626A1-B | 0.0948 | 0.0241 | 3.9339 | |||
UM626A1-R | 0.0948 | 0.0230 | 4.1162 | |||
UM650B-B | 0.0141 | 0.0037 | 3.7658 | |||
UM650B-R | 0.0070 | 0.0038 | 1.8372 | |||
K747_RS06360 | WP_015644959.1 | Transglycosylase SLT domain-containing protein (Cag4) | UM171-B | 0.0180 | 0.0180 | 6.4219 |
UM171-R | 0.0175 | 0.0175 | 5.3848 | |||
UM626A1-B | 0.0241 | 0.0241 | 3.8298 | |||
UM626A1-R | 0.0230 | 0.0230 | 4.0073 | |||
UM650B-B | 0.0037 | 0.0037 | 16.3223 | |||
UM650B-R | 0.0038 | 0.0038 | 15.9259 | |||
K747_RS06805 | WP_015645027.1 | Vacuolating cytotoxin domain-containing protein | UM171-B | 0.0568 | 0.0180 | 3.1475 |
UM171-R | 0.0509 | 0.0175 | 2.9048 | |||
UM626A1-B | 0.0586 | 0.0241 | 2.4298 | |||
UM626A1-R | 0.0591 | 0.0230 | 2.5651 | |||
UM650B-B | 0.0182 | 0.0037 | 4.8890 | |||
UM650B-R | 0.0215 | 0.0038 | 5.6153 | |||
K747_RS07265 | WP_015645103.1 | 16S rRNA (cytosine(1402)-N(4))-methyltransferase (RsmH) | UM171-B | 0.0335 | 0.0180 | 1.8547 |
UM171-R | 0.0432 | 0.0175 | 2.4666 | |||
UM626A1-B | 0.0443 | 0.0241 | 1.8364 | |||
UM626A1-R | 0.0292 | 0.0230 | 1.2654 | |||
UM650B-B | 0.0076 | 0.0037 | 2.0259 | |||
UM650B-R | 0.0108 | 0.0038 | 2.8239 |