Elevated plasma and bile levels of corisin, a microbiota-derived proapoptotic peptide, in patients with severe acute cholangitis

Table 4 Univariate and multivariate analysis of predictors of disease clinical grade

Variables	β	95% Confidence interval	P values
Univariate analysis
Body temperature	− 0.06840	− 0.4893 to 0.3525	0.7452
Blood platelets	− 0.005229	− 0.008410 to − 0.002048	0.0018
Blood total protein	− 0.1432	− 0.5465 to 0.2600	0.4784
Blood albumin	− 0.3704	− 0.7847 to 0.04396	0.0786
Blood direct bilirubin	0.1473	0.02161 to 0.2730	0.0228
Serum aspartate aminotransferase	− 0.0004470	− 0.001809 to 0.0009148	0.5123
Serum alanine transaminase	− 0.0004057	− 0.002493 to 0.0011681	0.6975
Serum γ-glutamyl transpeptidase	0.0004206	− 0.0004873–0.001329	0.3559
Serum amylase	− 0.001653	− 0.005628 to 0.0022323	0.4070
Serum C-reactive protein	0.05997	0.03570 to 0.08423	< 0.0001
Serum creatinine	0.2115	0.04711 to 0.3759	0.0128
Activated partial thromboplastin time	0.005191	− 0.02722 to 0.03760	0.7484
Prothrombin time	− 0.01032	− 0.2055–0.00007634	0.0484
Peripheral oxygen saturation	0.01428	− 0.008877 to 0.03744	0.2209
Plasma corisin	0.0001820	0.00004644 to 0.0004104	0.1156
Bile corisin	0.0004046	0.00002717 to 0.0007820	0.0362
Multivariate analysis
Blood platelets	− 0.002166	− 0.005095 to 0.0007623	0.1413
Blood albumin	0.04396	− 0.3469 to 0.4348	0.8199
Blood direct bilirubin	0.03063	− 0.09576 to 0.1570	0.6242
Serum C-reactive protein	0.04274	0.01417 to 0.07131	0.0047
Serum creatinine	− 0.1259	− 0.3268 to 0.07495	0.2103
Prothrombin time	− 0.006219	− 0.01510 to 0.002658	0.1628
Plasma corisin	0.0001760	0.000004075–0.0003480	0.0451
Bile corisin	0.0002167	− 0.0002312 to 0.0006646	0.3310

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